IPCC climate changeIntergovernmental Panel on Climate Change Chair Hoesung Lee, center, speaks during a press conference in Incheon, South Korea, on October 8, 2018. Preventing an extra single degree of heat could make a life-or-death difference in the next few decades for multitudes of people and ecosystems on this fast-warming planet.Ahn Young-joon/AP

Some of the world’s biggest challenges, including climate change and political violence, extend far beyond any one nation’s borders.

Global catastrophes can occur for a number of reasons, and the Global Challenges Foundation’s 2018 report highlights some of the main risks to humanity today. The foundation, created in 2012, works with researchers to publish annual reports on threats that could devastate at least 10% of the world’s population. This year’s report contributors include astrophysicist Martin Rees and multiple experts focused on disarmament affairs at the United Nations

According to the foundation, the next 50 years will set the pace for humanity’s survival in the next 10,000 years. 

“Why care now? Because so much is at stake, too little is done, and if we wait until later, caring may no longer matter,” the report’s authors said.

Take a look at the 10 greatest challenges facing humans right now.